Recent items from the news feeds of various BOINC projects.

[LHC@home] Maintenance downtime

Our BOINC services will be unavailable for a while this morning between 8 and 9AM CET for a database upgrade.

View article · Tue, 11 Mar 2025 06:16:13 +0000

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[YAFU] Aliquot sequence 3198912 has terminated!!!

Aliquot sequence 3198912 has terminated!!!

View article · Sat, 8 Mar 2025 20:27:35 +0000

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[YAFU] Aliquot sequence 2145360 has terminated!!!

Aliquot sequence 2145360 has terminated!!!

View article · Thu, 6 Mar 2025 20:30:08 +0000

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[Rosetta@home] Rosetta@home Update

First, we’d like to thank all our contributors who have supported and continue to contribute to our scientific projects through Rosetta@home. We want to update you on the status of Rosetta@home projects and our future plans.

With the advancement of AI models like AlphaFold and RosettaFold for protein structure predictions, Rosetta@home has been less used for this purpose. However, researchers are now utilizing Rosetta@home for small molecule and peptide designs, where even the current state-of-the-art AI models struggle due to limitations in generalizability to novel small molecules and non-canonical peptides.

Recently, we have developed a virtual screening protocol in Rosetta, named RosettaVS, for small molecule drug discovery. This work has been published in Nature Communications (https://doi.org/10.1038/s41467-024-52061-7), demonstrating that RosettaVS is one of the best physics-based virtual screening protocols. Combined with deep learning techniques, it can effectively screen multi-billion compound libraries and discover novel compounds for pharmaceutical targets.

While deep learning models like AlphaFold and RosettaFold can predict canonical peptide structures, they cannot handle peptides with non-canonical amino acids or mixed chirality. The physics-based force field in Rosetta has specialized terms to simulate these amino acids. Rosetta will be used to sample hundreds of thousands of different conformations of the designed peptide to validate the structure.

Looking ahead, Rosetta@home will be an invaluable platform for large-scale virtual screening and peptide simulations for drug discovery. We plan to launch more virtual screening jobs and peptide simulations on Rosetta@home in the near future.

Thank you!

View article · Tue, 4 Mar 2025 04:50:22 +0000

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[YAFU] Aliquot sequence 3075240 has terminated!!!

Aliquot sequence 3075240 has terminated!!!

View article · Thu, 27 Feb 2025 20:30:29 +0000

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[YAFU] Aliquot sequence 3129840 has terminated!!!

Aliquot sequence 3129840 has terminated!!!

View article · Mon, 24 Feb 2025 17:28:44 +0000

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[YAFU] Aliquot sequence 3146526 has terminated!!!

Aliquot sequence 3146526 has terminated!!!

View article · Thu, 20 Feb 2025 17:36:16 +0000

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[Einstein@home] Einstein@Home is twenty years old today!

I want to congratulate all of our Einstein@Home volunteers, developers, and scientists: our project is 20 years old today.  We officially launched Einstein@Home on February 19th 2005, exactly 20 years ago, at the annual meeting of the American Association for the Advancement of Science (AAAS) in Washington DC.

read more

View article · Wed, 19 Feb 2025 17:20:21 +0000

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[YAFU] YAFU version 212.02 for Linux

New version 212.02 for Linux.
If the app is in a later running phase and a nfs.dat file was created, resume should also work.

View article · Mon, 27 Jan 2025 20:16:26 +0000

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[DENIS@Home] Status of the project // Estado del proyecto

Dear Volunteers,

As you may have noticed, the task hiatus has extended longer than we would have liked. I apologize for not writing sooner, as I was hoping we could launch something earlier. However, given our current workload and the steps required for the new simulations, there will be no new tasks at least until the end of February.

I apologize for this decrease in activity; we will return as soon as possible.

Sincerely,
Jesús.

===============================================================

Estimados voluntarios:
Como habéis podido comprobar, el parón de tareas se ha extendido más de lo que nos habría gustado. Disculpad que no haya escrito antes porque esperaba que pudieramos lanzar algo antes, pero vista la carga de trabajo que tenemos y los pasos que requieren las nuevas simulaciones, no habrá nuevas tareas por lo menos hasta finales de febrero.

Disculpad esta bajada de actividad, volveremos lo antes posible.

Atentamente,
Jesús.

View article · Mon, 27 Jan 2025 09:45:23 +0000

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[YAFU] Aliquot sequence 3134280 and 3126990 have terminated!!!

Aliquot sequence 3134280 and 3126990 have terminated!!!

View article · Sun, 26 Jan 2025 13:36:23 +0000

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[Yoyo@home] sr2sieve wu needs much RAM

The workunits of the current S31 batch requiring 3 GB of RAM or more. Also workunits of the next R19 batch using much RAM.

View article · Tue, 21 Jan 2025 23:00:00 +0000

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[Minecraft@Home] High error rate on 'Loneliest Seed' tasks for older GPUs

Hi everyone,

I wanted to put this out there as I'm seeing a high error rate on tasks running on older GPUs.

I've spent a chunk of time digging into these, and the most prevalent error is a launch timeout error from the cuda driver.
This is a possible indication of either hardware failure, or a buggy driver.

If you see a lot of "Error 702" failing tasks, please update your drivers to the latest possible for your OS and video card, as there's potentially an issue with your current driver preventing work from completing on your card.

Please let us know if you have any questions, or need any help determining the issue.

Thanks!

View article · Fri, 17 Jan 2025 05:02:26 +0000

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[YAFU] Aliquot sequence 3112254 has terminated!!!

Aliquot sequence 3112254 has terminated!!!

View article · Thu, 16 Jan 2025 21:17:21 +0000

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[Minecraft@Home] The Loneliest Seed

Hi Folks!

We're back with another round of tasks. This time for Nvidia GPUs.

The first batch will have 262144 workunits (524288 tasks), but we anticipate that there will be far more in the future for this project fed in gradually. (Estimated 17.1 billion workunits possible).

Apologies for the lack of communication/delays the last few months. These days I'm the primary administrator on this project, and while I do pay attention to our discord more, I should do better to keep the community on the BOINC platform in the loop about future updates.

Beyond this project, we may have one other lined up (much smaller in scope than this 17.1 billion workunit project) and an overall platform upgrade that I've slowly been widdling away at these last few months as I find time.

I'll be pushing the new work tonight, so get your GPUs ready! They're available on Windows and Linux x86_64 machines.

Best Regards,

BoySanic

View article · Sun, 12 Jan 2025 03:57:41 +0000

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[YAFU] Aliquot sequence 3152874 has terminated!!!

Aliquot sequence 3152874 has terminated!!!

View article · Thu, 9 Jan 2025 16:56:27 +0000

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[Yoyo@home] sr2sieve wu runtime increased

I increased the runtime for sr2sieve workunits. They should now run twice as long as before.

View article · Fri, 3 Jan 2025 23:00:00 +0000

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[SETI@home] RIP Jimmy Carter

Carter wrote the following on June 16, 1977 and placed it in Voyager 1, which is the most distant human-made object from Earth:

This Voyager spacecraft was constructed by the United States of America. We are a community of 240 million human being among the more than 4 billion who inhabit the planet Earth. We human beings are still divided into nation states, but these states are rapidly becoming a single global civilization.

We cast this message into the cosmos. It is likely to survive a billion years into our future, when our civilization is profoundly altered and the surface of the Earth may be vastly changed. Of the 200 billion stars in the Milky Way galaxy, some – perhaps many – may have inhabited planet and spacefaring civilizations. If one such civilization intercepts Voyager and can understand these recorded contents, here is our message:

“This is a present from a small distant world, a token of our sounds, our science, our images, our music, our thoughts and our feelings. We are attempting to survive our time so we may live into yours. We hope someday, having solved the problem we face, to join a community of galactic civilizations. This record represents our hope and our determination, and our good will in a vast and awesome universe.”

--- Jimmy Carter, President of the United States of America, the White House, June 16, 1977

View article · Mon, 30 Dec 2024 09:27:36 +0000

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[YAFU] YAFU version 212 for Linux

On newer Linux versions yafu failed. I deployed version 212 for Linux for app yafu, which should fix this.
The new version is currently only for app yafu available. If this runs well it will be deployed also for all other versions.

Happy Christmas and a wonderful new year!

yoyo

View article · Wed, 25 Dec 2024 19:56:26 +0000

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[Yoyo@home] sr2sieve wu generation

I changed the workunit generation for sr2sieve workunits, workunits which are named sr2_*. The sieve range is now smaller and workunits are running faster. With this they are fitting also better die old CPUs and ARM processors.

View article · Mon, 23 Dec 2024 23:00:00 +0000

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[LHC@home] Seasons greetings

Merry Christmas and a peaceful end of the year from the LHC@home team!

Many thanks to all our volunteers for your crunching and contributions!

Here are some highlights from 2024 at CERN.

Greetings and best wishes for 2025!

View article · Fri, 20 Dec 2024 12:18:57 +0000

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[Yoyo@home] P75 ECM factor!

User user3928 found a 75-digit prime factor of an XYYXF number using ECM. This is the largest ECM factor found this year, and the 8th largest of all time.

View article · Tue, 17 Dec 2024 23:00:00 +0000

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